[Relations between chemical structure, physico-chemical properties, chemical reactivity and effect of various positionally isomeric local anesthetics 31.2.]
J Büchi, RJ Koller, X Perlia
文献索引：Buechi,J. et al. Arzneimittel Forschung, 1975 , vol. 25, p. 14 - 24
1. In the introduction, a short survey on the effect of different structural isomers on the activity of drugs is giben. The inductive, resonance and steric effect of the ring substitution are discussed and probable mechanism of local-anesthetic action is dealth with. 2. As model substances in this work, the diethylamino-ethyl-ester-hydrochlorides of amino-, butylamino, butoxy-and butyl-benzoic acids are synthesized and their purity tests as well as the ...
