[3H] N-2-(4-(N-Benzamido) phenyl) propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand

H Zarrinmayeh, D Bleakman, MR Gates…

文献索引：Zarrinmayeh; Bleakman; Gates; Yu; Zimmerman; Ornstein; McKennon; Arnold; Wheeler; Skolnick Journal of medicinal chemistry, 2001 , vol. 44, # 3 p. 302 - 304

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被引用次数: 28

摘要

Introduction. The AMPA (R-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of ionotropic glutamate receptor mediates fast excitatory neurotransmission at the majority of synapses in the mammalian central nervous system. Native AMPA receptors are likely constituted as heterooligomers, composed of one or more of the AMPA receptor subunits GluR1, 2, 3, and 4. 1 Like other ligand-gated ion channels, AMPA receptor function can be ...