The utility of 4-substituted prolinols and their corresponding prolines in peptides, peptidomimetics, and natural products has motivated researchers to find new and efficient routes for their preparation. Herein, we report a general approach to the synthesis of Boc- protected 4-alkylprolinols and prolines via a divergent asymmetric hydrogenation strategy. Intermediate exocyclic olefins were prepared by Wittig-type reactions with ketone 6 and ...
![(2S)-2-[[tert-Butyldimethylsilyloxy]Methyl]-4-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester结构式](https://image.chemsrc.com/caspic/051/220993-22-6.png)
