Abstract In search of structure-activity relationships among histamine H 3-receptor antagonists the imidazole ring of known H 3-receptor antagonists was replaced by different heteroaromatic ring systems. Thus, azines and diazines with ether (6–13) and carbamate (15–24) moieties as functional groups were synthesized. The obtained compounds did not show significant H 3-receptor antagonist activity in vitro (rat brain cortex) or in vivo (mice ...
