Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

…, X Chen, A Saldivar, S Vasavanonda, DJ Kempf…

文献索引：Sham, Hing L.; Betebenner, David A.; Chen, Xiaoqi; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1185 - 1187

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被引用次数: 20

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2′ position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure–activity relationships explored.