Tetrahedron letters

Thermal and microwave-assisted N-formylation using solid-supported reagents

B Desai, TN Danks, G Wagner

文献索引：Desai, Bimbisar; Danks, Timothy N.; Wagner, Gabriele Tetrahedron Letters, 2005 , vol. 46, # 6 p. 955 - 957

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被引用次数: 46

摘要

A rapid and easy route to formamides by microwave assisted N-formylation of primary and secondary amines is described. Using an insoluble polymer or an inorganic solid-supported reagent as a formylating agent, microwave irradiation furnished the corresponding formamides in high yields, with reduced reaction time and solvent volume over the conventional approach.