Unsymmetrical non-adamantyl N, N′-diaryl urea and amide inhibitors of soluble expoxide hydrolase

SK Anandan, HK Webb, ZN Do, RD Gless

文献索引：Anandan, Sampath-Kumar; Webb, Heather K.; Do, Zung N.; Gless, Richard D. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4259 - 4263

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被引用次数: 17

摘要

Incorporation of an adamantyl group in prototypical soluble expoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. We explored replacement of the adamantyl group in unsymmetrical ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors. We found that aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded ...