Total Synthesis of the (+)??Antimycin A Family

…, H Kaku, M Horikawa, T Tsunoda

文献索引：Inai, Makoto; Nishii, Takeshi; Tanaka, Ayako; Kaku, Hiroto; Horikawa, Mitsuyo; Tsunoda, Tetsuto European Journal of Organic Chemistry, 2011 , # 14 p. 2719 - 2729

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被引用次数: 4

摘要

Abstract An asymmetric aldol reaction using Oppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24%) to 12 compounds of the Antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60–300 mg scale. In the syntheses, the nine-membered dilactone ring was constructed successfully by lactonization of a 2-pyridinethiol ester bearing a TIPS group on the 8-OH by using the ( ...