Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation

M Croisy-Delcey, A Croisy, D Carrez, C Huel…

文献索引：Croisy-Delcey, Martine; Croisy, Alain; Carrez, Daniele; Huel, Christiane; Chiaroni, Angele; Ducrot, Pierre; Bisagni, Emile; Jin, Lu; Leclercq, Guy Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 11 p. 2629 - 2641

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被引用次数: 95

摘要

The synthesis of a series of 35 substituted 3, 4-diphenyl quinolines and isoquinolines is described. The majority of these molecules differ from all other triphenylethylene based antiestrogens by a different spatial location of the aminoalkyl side chain. The binding affinity of the most representative molecules (8, 9, 19, 20, 21, 23 and 25), including analogues 8 and 21 without the side chain, for the estrogen receptor α (ER)† was determined. The ...