Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo [4, 5-c] quinolin-4-one derivatives bearing different substituents …

…, F Varano, O Lenzi, G Filacchioni, C Costagli…

文献索引：Calabri, Francesca Romana; Colotta, Vittoria; Catarzi, Daniela; Varano, Flavia; Lenzi, Ombretta; Filacchioni, Guido; Costagli, Chiara; Galli, Alessandro European Journal of Medicinal Chemistry, 2005 , vol. 40, # 9 p. 897 - 907

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被引用次数: 23

摘要

The synthesis and biological evaluation at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo [4, 5-c] quinolin-4-one derivatives are reported. Different substituents were introduced at the 2-position (mercapto, carbonyl and methyl groups) and on the fused benzo ring (chlorine atom (s) and trifluoromethyl group). Among the herein reported compounds, the 2-mercapto-derivatives 1–4 showed the highest Gly/NMDA affinities, comparable to ...