Synthesis of gossypol analogues

VI Ognyanov, OS Petrov, EP Tiholov…

文献索引：Ognyanov; Petrov; Tiholov; Mollov Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 353 - 360

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被引用次数: 20

摘要

Abstract Two gossypol analogues 2a and 2b were synthesized for biological evaluation as male contraceptive agents. The naphthol 8c was prepared by analogy with a known procedure starling from 3-isopropylcatechol (3).(t-Bu) 2 O 2-Mediated phenolic coupling of 8c furnished the binaphthol 9c which, after pyrane ring closure, deprotection. and selective bisformylation with SnCl 4/Cl 2 CHOCH 3, gave the target compound 2a. The ...