Ring-Opening Hydrofluorination of 2, 3-and 3, 4-Epoxy Amines by HBF4· OEt2: Application to the Asymmetric Synthesis of (S, S)-3-Deoxy-3-fluorosafingol
…, MJ Morris, PM Roberts, JE Thomson
文献索引：Bull, James R.; Thomson, Russell I. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 241 - 252
Treatment of a range of 2, 3-and 3, 4-epoxy amines with HBF4· OEt2 at room temperature results in fast and efficient SN2-type ring-opening hydrofluorination to give stereodefined amino fluorohydrins. Operational simplicity, scalability, and short reaction time at ambient
