Synthesis and evaluation of new carbonic anhydrase inhibitors

…, Y Zhang, J Liu, D Zhang, Y Meng, L Wang…

文献索引：Xiao, Zhonghai; Duan, Ruifeng; Cui, Wenyu; Zhang, Yanfang; Zhang, Shouguo; Chen, Fangjin; Zhang, Yankun; Liu, Jiaying; Zhang, Dongxiang; Meng, Yuan; Wang, Lin; Wang, Hai Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3221 - 3228

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被引用次数: 3

摘要

Abstract A series of new sulfamide derivatives have been synthesized, their structures were confirmed by 1 H NMR and ESI-MS. Some target compounds were assessed by the tool of Dock6, and inhibition effects of all the new compounds on carbonic anhydrase II have been investigated. In addition, some compounds have been investigated for their antihypoxic effects in mice. Results indicated that nine target compounds exhibit as effectively as ...