Studies on the narciclasine alkaloids: total synthesis of (+)-narciclasine and (+)-pancratistatin

JH Rigby, USM Maharoof…

文献索引：Rigby, James H.; Maharoof, Umar S. M.; Mateo, Mary E. Journal of the American Chemical Society, 2000 , vol. 122, # 28 p. 6624 - 6628

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被引用次数: 112

摘要

Enantioselective total syntheses of the antitumor alkaloids,(+)-narciclasine and (+)- pancratistatin, are reported. These syntheses feature a stereo-and regiocontrolled aryl enamide photocyclization to construct a common, advanced intermediate possessing a trans- fused BC substructure. Differential functional group interchange in the C-ring of this phenanthridone core structure allows for the production of the two target natural products ...