Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity

P Pelkonen, MA Lang, M Negishi, CP Wild…

文献索引：Pelkonen; Lang; Negishi; Wild; Juvonen Chemical research in toxicology, 1997 , vol. 10, # 1 p. 85 - 90

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被引用次数: 37

摘要

Among members of the mouse cytochrome P450 2A family, P450 2A5 is the best catalyst of aflatoxin B1 (AFB1) oxidation to its 8, 9-epoxide (Pelkonen, P., Lang, M., Wild, CP, Negishi, M., and Juvonen, RO (1994) Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 292, 67- 73). Here we studied the role of amino acid residues 209 and 365 of the P450 2A5 in the metabolism and toxicity of AFB1 using recombinant yeasts. The two sites have previously ...