Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil

…, Y Li, T Gong, X Sun, Y Fu, Q He, Z Zhang

文献索引：Xuan, Zhang; Xing, Liu; Tao, Gong; Xun, Sun; Zhang, Zhi-Rong Acta Pharmacologica Sinica, 2012 , vol. 33, # 2 p. 279 - 288

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被引用次数: 4

摘要

The blood brain barrier (BBB) represents the biggest challenge for therapeutic drugs to enter the brain. In our study, we selected chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. Here, we