Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression

…, JL Meagher, JA Stuckey, S Wang

文献索引：Tang, Guozhi; Nikolovska-Coleska, Zaneta; Qiu, Su; Yang, Chao-Yie; Guo, Jie; Wang, Shaomeng Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 717 - 720

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被引用次数: 23

摘要

Bcl-2 and Bcl-xL antiapoptotic proteins are attractive cancer therapeutic targets. We have previously reported the design of 4, 5-diphenyl-1 H-pyrrole-3-carboxylic acids as a class of potent Bcl-2/Bcl-xL inhibitors. In the present study, we report our structure-based