Synthesis and Structure− Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D

K Bravo-Altamirano, KM George…

文献索引：Bravo-Altamirano, Karla; George, Kara M.; Frantz, Marie-Celine; Lavalle, Courtney R.; Tandon, Manuj; Leimgruber, Stephanie; Sharlow, Elizabeth R.; Lazo, John S.; Wang, Q. Jane; Wipf, Peter ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 2 p. 154 - 159

全文：HTML全文

被引用次数: 19

摘要

Protein kinase D (PKD) is a member of a novel family of serine/threonine kinases that regulate fundamental cellular processes. PKD is implicated in the pathogenesis of several diseases, including cancer. Progress in understanding the biological functions and therapeutic potential of PKD has been hampered by the lack of specific inhibitors. The benzoxoloazepinolone CID755673 was recently identified as the first potent and selective ...