Structure–activity relationships of 3, 4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

…, TT Nguyen, TD Osslund, D Powers, VJ Santora…

文献索引：Rzasa, Robert M.; Kaller, Matthew R.; Liu, Gang; Magal, Ella; Nguyen, Thomas T.; Osslund, Timothy D.; Powers, David; Santora, Vincent J.; Viswanadhan, Vellarkad N.; Wang, Hui-Ling; Xiong, Xiaoling; Zhong, Wenge; Norman, Mark H. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 20 p. 6574 - 6595

全文：HTML全文

被引用次数: 33

摘要

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that plays a critical role in the early development of the nervous system. Deregulation of CDK5 is believed to contribute to the abnormal phosphorylation of various cellular substrates associated with neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. Acyclic urea 3 was identified as a potent CDK5 inhibitor and co- ...