Non-peptidic inhibitors of human neutrophil elastase: the design and synthesis of sulfonanilide-containing inhibitors

…, T Okada, Y Nakayama, Y Nagao, K Kobayashi…

文献索引：Imaki, Katsuhiro; Okada, Takanori; Nakayama, Yoshisuke; Nagao, Yuuki; Kobayashi, Kaoru; Sakai, Yasuhiro; Mohri, Tetsuya; Amino, Takaaki; Nakai, Hisao; Kawamura, Masanori Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2115 - 2134

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被引用次数: 23

摘要

A novel series of pivaloyloxy benzene derivatives has been identified as potent and selective human neutrophil elastase (HNE) inhibitors. Convergent syntheses were developed in order to identify the inhibitors which are intravenously effective in an animal model. A compound of particular interest is the sulfonanilide-containing analogues. Structure-activity relationships are discussed. Structural requirements for metabolic ...