Synthesis and biological evaluation of a novel series of furans: ligands selective for estrogen receptor α

…, KE Carlson, J Sun, BS Katzenellenbogen…

文献索引：Mortensen; Rodriguez; Carlson; Sun; Katzenellenbogen Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3838 - 3848

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被引用次数: 224

摘要

A variety of nonsteroidal systems can function as ligands for the estrogen receptor (ER), in some cases showing selectivity for one of the two ER subtypes, ERα or ERβ. We have prepared a series of heterocycle-based (furans, thiophenes, and pyrroles) ligands for the estrogen receptor and assessed their behavior as ER ligands. An aldehyde enone conjugate addition approach and an enolate alkylation approach were developed to ...