Tetrahedron

Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor

Y Suzuki, C Sugiyama, O Ohno, K Umezawa

文献索引：Suzuki, Yoshikazu; Sugiyama, Chie; Ohno, Osamu; Umezawa, Kazuo Tetrahedron, 2004 , vol. 60, # 33 p. 7061 - 7066

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被引用次数: 59

摘要

NF-κB is a transcription factor that induces inflammatory cytokines and anti-apoptotic proteins. We have designed a new NF-κB inhibitor based on the structure of the antibiotic epoxyquinomicin C. The designed compound, dehydroxymethylepoxyquinomicin ( ...