Fluspirilen (1) and Penfluridol (2), two neuroleptic agents, belong to a wide class of pharmaceuticals that contain in their molecules a 4, 4-bis (p-fluorophenyl) butyl group bound to a nitrogen atom of a pyrrolidine, piperidine or piperazine moiety. A key intermediate for the synthesis of compounds 1 and 2, 4, 4-bis (p-fluorophenyl) butylbromide (15), has been prepared starting from commercially available 4, 4′-difluorobenzophenone (7) following ...
![1,1'-(4-bromobutylidene)bis[4-fluorobenzene]结构式](https://image.chemsrc.com/caspic/421/57668-61-8.png)
![4-[4-氯-3-(三氟甲基)苯基]-4-羟基哌啶结构式](https://image.chemsrc.com/caspic/354/21928-50-7.png)
