Design and synthesis of novel quinolinone-3-aminoamides and their α-lipoic acid adducts as antioxidant and anti-inflammatory agents

…, O Igglessi-Markopoulou, C Kontogiorgis…

文献索引：Detsi, Anastasia; Bouloumbasi, Dionysia; Prousis, Kyriakos C.; Koufaki, Maria; Athanasellis, Giorgos; Melagraki, Georgia; Afantitis, Antreas; Igglessi-Markopoulou, Olga; Kontogiorgis, Christos; Hadjipavlou-Litina, Dimitra J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2450 - 2458

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被引用次数: 68

摘要

A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the α- lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent ...