Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system

…, K Yamada, M Mitani, N Kubota, N Kawakatsu…

文献索引：Kimura, Makoto; Masuda, Tomoko; Yamada, Koji; Mitani, Masaki; Kubota, Nobuo; Kawakatsu, Nobuyuki; Kishii, Kenichi; Inazu, Masato; Kiuchi, Yuji; Oguchi, Katsuji; Namiki, Takayuki Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1621 - 1630

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被引用次数: 18

摘要

A new series of diphenyl piperazine derivatives containing the phenyl substituted aminopropanol moiety, which were modified at sites between the diphenyl and piperazine moieties, was prepared and evaluated for dopamine transporter binding affinity with [3H] GBR12935 in rat striatal membranes. These synthesized compounds showed apparent dopamine transporter binding affinities (IC50< 30 nM) and some of them were ...