Imidodisulfamides. 2. Substituted 1, 2, 3, 4-tetrahydroisoquinolinylsulfonic imides as antagonists of slow-reacting substance of anaphylaxis

…, JG Gleason, DT Hill, RD Krell, CH Kruse…

文献索引：Ali; Gleason; Hill; Krell; Kruse; Lavanchy; Volpe Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1235 - 1240

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被引用次数: 11

摘要

SRS-A antagonist activities as evaluated by their ability to prevent SRS-A induced contractions of guinea pig ileum. In order for us to assess the influence of some aspects of conformation on SRS-A antagonist potency, the alkylene side chain was modified by incorporation into carbocyclic or fused heterocyclic ring systems. Among the cyclic structures studied, the tetrahydroisoquinoline series 4 afforded the most potent and selective ...