A Divergent Synthesis of Essentially Enantiopure syn-and anti-Propionate Aldol Adducts Based on the Chiral 1, 3, 2-Oxazaborolidin-5-one-Promoted Asymmetric …
S Kiyooka, KA Shahid
文献索引：Kiyooka; Shahid Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 8 p. 1485 - 1495
Essentially, enantiopure syn-and anti-propionate aldol adducts were divergently synthesized using a novel strategy which utilizes both the highly enantioselective 1, 3, 2- oxazaborolidin-5-one-promoted aldol reaction with a ketene silyl acetal derived from ethyl 2- bromo propionate and a highly diastereoselective radical debromination reaction. These procedures provide yields that increase to a level available for practical synthesis.
