The Synthesis of DL-α-Amino-β-(6-methyl-3-indazolyl)-propionic Acid

HR Snyder, JK Williams

文献索引：Snyder; Williams Journal of the American Chemical Society, 1954 , vol. 76, p. 1298,1300

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被引用次数: 2

摘要

In connection with studies of the antimetabolic activity of substances related to tryptophan the indazole analog of 6-methyltryptophan has been prepared. The steps employed in the synthesis are shown in the accompanying equations. The nitro-P-xylene (I) was prepared as reported previously. 2 The sodium enolate of ethyl 2-nitro-4-methylphenylpyruvate (11) separated as a dark purple solid when I was allowed to react with diethyl oxalate and ...