Tetrahedron: Asymmetry

Alternative and complementary approaches to the asymmetric synthesis of C3 substituted NH free or N-substituted isoindolin-1-ones

…, A Couture, E Deniau, P Grandclaudon

文献索引：Lamblin, Marc; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre Tetrahedron Asymmetry, 2008 , vol. 19, # 1 p. 111 - 123

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被引用次数: 48

摘要

Complementary synthetic approaches to enantiomerically pure C3 alkylated or arylated NH free or N-substituted isoindolinones have been developed. The key step is elaboration of diversely substituted 2-alkyl-and arylbenzylamines, which can be submitted to a bis- metallation process followed by interception with a carbonylating agent. They can be also converted into N-alkylbromobenzylcarbamates or into bromobenzyldicarbamates and the ...