Abstract Eighteen novel ω-(5-Aryl-1, 3.4-oxadiazol-2-thio)-ω-(1-H-1, 2, 4-triazol-1-yl) acetophenones (4a-4i) and ω-(5-Aryl-1, 3, 4-oxadiazol-2-thioacetoxyl)-ω-(1-H-1, 2, 4-triazol- 1-yl) acetophenones (5a-5i) were synthesized. All the compounds synthesized were confirmed by elemental analyses and spectral data. The biological activity of representative compounds was evaluated.