Synthesis and structure-activity relationships of 3-[(2-methyl-1, 3-thiazol-4-yl) ethynyl] pyridine analogues as potent, noncompetitive metabotropic glutamate receptor …

…, E Grajkowska, JT Wroblewski, J Davis…

文献索引：Iso, Yasuyoshi; Grajkowska, Ewa; Wroblewski, Jarda T.; Davis, Jared; Goeders, Nicholas E.; Johnson, Kenneth M.; Sanker, Subramaniam; Roth, Bryan L.; Tueckmantel, Werner; Kozikowski, Alan P. Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1080 - 1100

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被引用次数: 84

摘要

Recent genetic and pharmacological studies have suggested that the metabotropic glutamate receptor subtype 5 (mGluR5) may represent a druggable target in identifying new therapeutics for the treatment of various central nervous system disorders including drug abuse. In particular, considerable attention in the mGluR5 field has been devoted to identifying ligands that bind to the allosteric modulatory site, distinct from the site for the ...