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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl) aminobenzophenones as open-ring derivatives of …

K Hirai, T Ishiba, H Sugimoto, T Fujishita…

文献索引：Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27

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被引用次数: 15

摘要

Peptidoaminobenzophenones (l), terminal N-substituted peptidoaminobenzophenones (14), and acylglycylaminobenzophenones (16) were prepared as a novel series of ring-opened derivatives of 1, 4-benzodiazepine. Z-Gly-and Z-Ala-N-methylaminobenzophenones (4) were treated with HBr-HOAc to give Gly-and Ala-N-methylaminobenzophenone hydrobromides (8). Reaction of 8 with chloroacetyl chloride in dimethylformamide (DMF) ...

[2-Benzoyl-4-chlor-phenyl-carbamoylmethyl]-carbaminsaeure-benzylester结构式

[2-Benzoyl-4-ch...

~%

2-amino-N-(2-benzoyl-4-chlorophenyl)acetamide结构式

2-amino-N-(2-be...

六氢吡啶结构式

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~97%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-piperidin-1-ylacetyl)amino]acetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-piperidin-1-ylacetyl)amino]acetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-piperidin-1-ylacetyl)amino]acetamide结构式

N-[4-chloro-2-(...

未登录结构式

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-piperidin-1-ylacetyl)amino]acetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-piperidin-1-ylacetyl)amino]acetamide结构式

N-[4-chloro-2-(...

2-([(benzyloxy)carbonyl]amino)-2-phenylacetic acid结构式

2-([(benzyloxy)...

~%

benzyl N-(2-chloro-2-oxo-1-phenylethyl)carbamate结构式

benzyl N-(2-chl...

未登录结构式

~65%

2-acetamido-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-acetamide结构式

2-acetamido-N-[...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

乙酰氯结构式

~47%

2-acetamido-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-acetamide结构式

2-acetamido-N-[...

2-methylamino-5,2'-dichlorobenzhydrol结构式

2-methylamino-5...

~%

2-acetamido-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-acetamide结构式

2-acetamido-N-[...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

2-acetamido-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-acetamide结构式

2-acetamido-N-[...

未登录结构式

~%

2-acetamido-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-acetamide结构式

2-acetamido-N-[...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide结构式

4-chloro-2-(o-c...

二乙胺结构式

~90%

2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-N-[2-(diethylamino)acetyl]acetamide结构式

2-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-N-[2-(diethylamino)acetyl]acetamide结构式

2-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-N-[2-(diethylamino)acetyl]acetamide结构式

2-[4-chloro-2-(...

未登录结构式

~%

2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-N-[2-(diethylamino)acetyl]acetamide结构式

2-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~%

2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-N-[2-(diethylamino)acetyl]acetamide结构式

2-[4-chloro-2-(...

4-(4-氯苯基)-4-羟基哌啶结构式

4-(4-氯苯基)-4-羟基哌啶

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~87%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]acetyl]amino]-N-methylacetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]acetyl]amino]-N-methylacetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]acetyl]amino]-N-methylacetamide结构式

N-[4-chloro-2-(...

未登录结构式

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]acetyl]amino]-N-methylacetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]acetyl]amino]-N-methylacetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~28%

氯扎封结构式

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

氯扎封结构式

未登录结构式

~%

氯扎封结构式

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~%

氯扎封结构式

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

氯扎封结构式

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~92%

N-[2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-2-oxoethyl]pentanamide结构式

N-[2-[4-chloro-...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-2-oxoethyl]pentanamide结构式

N-[2-[4-chloro-...

未登录结构式

~%

N-[2-[4-chloro-2-(2-chlorobenzoyl)-N-methylanilino]-2-oxoethyl]pentanamide结构式

N-[2-[4-chloro-...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~45%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]hexad ecanamide结构式

N-[[[4-chloro-2...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]hexad ecanamide结构式

N-[[[4-chloro-2...

未登录结构式

~%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]hexad ecanamide结构式

N-[[[4-chloro-2...

2-amino-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)acetamide hydrobromide结构式

2-amino-N-(4-ch...

乙酰氯结构式

~91%

2-(Acetylamino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)acetamide结构式

2-(Acetylamino)...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

2-(Acetylamino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)acetamide结构式

2-(Acetylamino)...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~84%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-phenylacetyl)ami no]acetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-phenylacetyl)ami no]acetamide结构式

N-[4-chloro-2-(...

未登录结构式

~%

N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N-methyl-2-[(2-phenylacetyl)ami no]acetamide结构式

N-[4-chloro-2-(...

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide结构式

4-chloro-2-(o-c...

~85%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]butan amide结构式

N-[[[4-chloro-2...

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide结构式

4-chloro-2-(o-c...

~%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]butan amide结构式

N-[[[4-chloro-2...

未登录结构式

~%

N-[[[4-chloro-2-(2-chlorobenzoyl)phenyl]-methyl-carbamoyl]methyl]butan amide结构式

N-[[[4-chloro-2...

未登录结构式

~94%

N-(2-Benzoyl-4-nitrophenyl)-glycyl-glycinamide hydrobromide hydrate (2 :2:1)结构式

N-(2-Benzoyl-4-...

benzyl (2-((2-benzoyl-4-nitrophenyl)amino)-2-oxoethyl)carbamate结构式

benzyl (2-((2-b...

~%

N-(2-Benzoyl-4-nitrophenyl)-glycyl-glycinamide hydrobromide hydrate (2 :2:1)结构式

N-(2-Benzoyl-4-...

2-amino-N-(2-benzoyl-4-nitrophenyl)acetamide hydrobromide结构式

2-amino-N-(2-be...

~%

N-(2-Benzoyl-4-nitrophenyl)-glycyl-glycinamide hydrobromide hydrate (2 :2:1)结构式

N-(2-Benzoyl-4-...