Synthesis of benzimidazole derivatives as potential H1??antihistaminic agents

R Iemura, T Kawashima, T Fukuda, K Ito…

文献索引：Iemura; Kawashima; Fukuda; et al. Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 31 - 37

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被引用次数: 27

摘要

Abstract Several types of benzimidazole derivatives were prepared and were screened for H 1-antihistaminic activity. Most of the compounds showed potent antihistaminic activity in vitro. Among them 2-[(1-piperazinyl) methyl]-benzimidazoles 14 and 2-[(1-homopiperazinyi) methyl] benzimidazoles 15 exhibited potent activity also in vivo.