Journal of medicinal chemistry

Synthesis and antimetastatic properties of stereoisomeric tricyclic bis (dioxopiperazines) in the Lewis lung carcinoma model

DT Witiak, RV Nair, FA Schmid

文献索引：Witiak, Donald T.; Nair, Raghunathan V.; Schmid, Franz A. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1228 - 1234

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被引用次数: 13

摘要

W 13, RsCHzN 0 in acetone. Later reports by Hino and Sato14J5 indicated that ethyl aminomalonate did not dimerize to 21 at elevated temperatures. Our results were in agreement with these later reports; ethyl aminomalonate prepared according to the method of Schipper and Day16 could not be dimerized under various conditions. We therefore investigated the dioxopiperazinediol24 as a possible precursor to the ...