ChemMedChem

Synthesis and Anti??Plasmodium Activity of Benzimidazole Analogues Structurally Related to Astemizole

G Roman, IE Crandall, WA Szarek

文献索引：Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A. ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804

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被引用次数: 4

摘要

Abstract A series of compounds structurally related to astemizole were designed and synthesized with the goal of determining their anti-Plasmodium activity. Several modifications of the astemizole structure, namely the removal of the 4-fluorobenzyl and/or 4- methoxyphenethyl moieties, substitution of the benzene ring of the benzimidazole scaffold, replacement of the fluorine atom in the 4-fluorobenzyl group, and variation of the 4- ...