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Brush-border-enzyme-mediated intestine-specific drug delivery. Amino acid prodrugs of 5-aminosalicylic acid

R Pellicciari, A Garzon-Aburbeh…

文献索引:Pellicciari, Roberto; Garzon-Aburbeh, Aaron; Natalini, Benedetto; Marinozzi, Maura; Clerici, Carlo; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4201 - 4207

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被引用次数: 19

摘要

Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), remain a problem to be solved by the biomedical community. Centered on the treatment with corticosteroids and salicylates, the medical therapy of IBD is still empirical due to an inadequate knowledge of the pathogenesis and a lack of understanding about the etiology of the disease. lt2 Corticosteroids such as the newer fluticasone? beclometasone, ...