Synthesis

Alkylation of camphor and pinanone imines of 2-(aminomethyl) thiazole. Enantioselective synthesis of 2-(1-aminoalkyl) thiazoles

A Dondoni, FL Merchan, P Merino, I Rojo, T Tejero

文献索引：Dondoni, Alessandro; Merchan, Francisco L.; Merino, Pedro; Rojo, Isabel; Tejero, Tomas Synthesis, 1996 , # 5 p. 641 - 646

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被引用次数: 13

摘要

A method is described for the enantioselective synthesis of 2-(1-aminoalkyl) thiazoles 6 via stereoselective alkylation of the carbanions of (+)-(R)-camphor and (—)-(1 S, 2S, 5S)-2- hydroxypinan-3-one imines 2 and 3 derived from 2-(aminomethyl) thiazole (2-AMT, 1). Compounds 6 serve as or-amino aldehyde precursors via thiazolylto-formyl conversion.