Practical synthesis of FR195752, the side chain of micafungin, utilizing a regioselective conversion of diaryl-β-diketone to 3, 5-diarylisoxazole

A Ohigashi, A Kanda, H Tsuboi…

文献索引：Organic Process Research and Development, , vol. 9, # 2 p. 179 - 184

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被引用次数: 11

摘要

... Organic Process Research & Development. ... However, this process had to be abandoned because it proved to be impossible to obtain pure 4a from the mixture ... During the research of regioselective activation of 6a, we discovered that β-diketone 6a readily reacted with AcONH 4 ...