Tetrahedron

Investigation of the scope and mechanism of copper catalyzed regioselective methylthiolation of aryl halides

PJA Joseph, S Priyadarshini, ML Kantam, B Sreedhar

文献索引：Joseph, P.J. Amal; Priyadarshini; Kantam, M. Lakshmi; Sreedhar Tetrahedron, 2013 , vol. 69, # 38 p. 8276 - 8283

被引用次数: 12

摘要

Abstract Methylthiolation of structurally diverse aryl halides was accomplished under fluoride free conditions using catalytic amounts of CuI, and DMSO as the methylthiolation source. Optimization studies unveiled several varieties of promoters among which Zn (OAc) 2 was found ideal. The analogous reaction with DMSO-d 6 afforded corresponding deuterated aryl methyl thioether with 99% purity. Mechanistic studies revealed CuSMe as the active ...

6698-13-1

4-溴-1,3-苯并二恶唑

~76%

~83%

~75%

~83%

~96%

~58%

~90%

~96%

~80%

~98%

~84%

~86%

~87%

~78%

~71%

~96%

Synthesis of 6, 7??methylenedioxy??3, 4??dihydro??1??methylb...

[Ruffin, L. D.; Bowlus, S. B. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 461 - 462]