Tetrahedron letters

Convenient synthesis of N-(4-(2-aminopyridin-4-yl) thiazol-2-yl)-2-phenylacetamides

UK Bandarage, JH Come, J Green

文献索引：Bandarage, Upul K.; Come, Jon H.; Green, Jeremy Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8079 - 8081

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被引用次数: 4

摘要

As a part of our medicinal chemistry research program, we were interested in synthesizing N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides 1. The synthesis of this class of compounds has not been previously reported to our knowledge. The most straightforward synthetic approach to introduce an amino group at the 2-position of pyridine is by thermal or microwave assisted reaction of benzylamines with 2-chloro or 2-fluoropyridines 2 to afford 3, 1 or by transition ...