Tetrahedron

Synthesis of phospholipids on a glyceric acid scaffold: design and preparation of phospholipase A 2 specific substrates

R Rosseto, J Hajdu

文献索引：Rosseto, Renato; Hajdu, Joseph Tetrahedron, 2014 , vol. 70, # 19 p. 3155 - 3165

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被引用次数: 2

摘要

Abstract Synthesis of a new series of phospholipid analogues to serve as activity-based probes of secretory phospholipase A 2 enzymes is reported. The synthesis is based upon (1) preparation of long-chain esters and amides of glyceric acid, followed by (2) regioselective derivatization of the diol function of the molecule to achieve phosphorylation at the primary hydroxyl group, and to introduce the incipient sn-2-ester group of the target ...