European journal of medicinal chemistry

Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

M Zhang, W Zhu, Y Li

文献索引：Zhang, Mingming; Zhu, Weiliang; Li, Yingxia European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 301 - 310

全文：HTML全文

被引用次数: 7

摘要

Inhibition of the signal transducer and activator of transcription 3 (STAT3) signaling pathway has been considered a novel therapeutic strategy to treat human cancers that harbor aberrantly-active STAT3. In this study, nearly 204,000 compounds in Specs database were screened by virtual screening, and samples of top 100 compounds identified as candidate small-molecule inhibitors of STAT3 were evaluated by STAT3-dependent luciferase ...