Synthesis and Kinetic Testing of Tetrahydropyrimidine??2??thione and Pyrrole Derivatives as Inhibitors of the Metallo?螃漫?lactamase from Klebsiella pneumonia and …

…, ZM Mohamed, RP McGeary, G Schenk…

文献索引：Hussein, Waleed M.; Fatahala, Samar S.; Mohamed, Zainab M.; Mcgeary, Ross P.; Schenk, Gerhard; Ollis, David L.; Mohamed, Mosaad S. Chemical Biology and Drug Design, 2012 , vol. 80, # 4 p. 500 - 515

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被引用次数: 23

摘要

Metallo-b-lactamases (MBLs), produced by an increasing number of bacterial pathogens, facilitate the hydrolysis of many commonly used b-lactam antibiotics. There are no clinically useful antagonists against MBLs. Two sets of tetrahydropyrimidine-2-thione and pyrrole derivatives were synthesized and assayed for their inhibitory effects on the catalytic activity of the IMP-1 MBL from Pseudomonas aeruginosa and Klebsiella pneumoniae. Nine ...