文献索引：Faridoon; Hussein, Waleed M.; Ul Islam, Nazar; Guddat, Luke W.; Schenk, Gerhard; McGeary, Ross P. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2555 - 2559
Purple acid phosphatases (PAPs) are binuclear metallohydrolases that have a multitude of biological functions and are found in fungi, bacteria, plants and animals. In mammals, PAP activity is linked with bone resorption and over-expression can lead to bone disorders such as osteoporosis. PAP is therefore an attractive target for the development of drugs to treat this disease. A series of penicillin conjugates, in which 6-aminopenicillanic acid was ...
