Aminopyridine carbamic acid esters: Synthesis and potential as acetylcholinesterase inhibitors and acetylcholine releasers

GM Shutske, JD Tomer, KJ Kapples…

文献索引：Shutske; Tomer; Kapples; Hrib; Jurcak; Bores; Huger; Petko; Smith Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 4 p. 380 - 385

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被引用次数: 4

摘要

Abstract 4-Amino-3-pyridyl carbamates (2a-c) were synthesized as potential acetylcholinesterase inhibitors and acetylcholine releasers on the basis of the reported activity of the analogous N-(4-amino-3-pyridyl)-N', N'-dimethylurea (1). Although 4-amino-3- pyridyl N, N-dimethylcarbamate (2b) showed good cholinesterase inhibition [concentration that elicited a 50% reduction in the maximal enzyme response (IC 50) was 13.4 μM], it had ...