A structure–activity relationship study of 1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazin-5, 7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated …

H Bera, BJ Tan, L Sun, AV Dolzhenko, WK Chui…

文献索引：Bera, Hriday; Tan, Bee Jen; Sun, Lingyi; Dolzhenko, Anton V.; Chui, Wai-Keung; Chiu, Gigi Nagar Chee European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 325 - 334

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被引用次数: 14

摘要

Abstract Thirty-three 1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazin-5, 7-dione and its 5-thioxo analogues were designed and synthesized which contained different substituents at meta- and/or para-positions of 2-phenyl or 2-benzyl ring attached to the fused ring structure. The preliminary pharmacological evaluation demonstrated that the 5-thioxo analogues of 1, 2, 4- triazolo [1, 5-a][1, 3, 5] triazine exhibited a varying degree of inhibitory activity towards ...