Synthesis

Palladium-Catalyzed Cross-Couplings of Lithium Arylzincates with Aromatic Halides: Synthesis of Analogues of Isomeridianin G and Evaluation as GSK-3β Inhibitors

A Seggio, G Priem, F Chevallier, F Mongin

文献索引：Seggio, Anne; Priem, Ghislaine; Chevallier, Floris; Mongin, Florence Synthesis, 2009 , # 21 p. 3617 - 3632

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被引用次数: 11

摘要

Abstract Several analogues of isomeridianin G have been synthesized using palladium- catalyzed cross-coupling reactions of lithium triorganozincates as a key step. The latter have been prepared by deprotonative lithiation followed by transmetalation using ZnCl 2 TMEDA (0.33 equiv).