Synthesis of novel substituted pyridines as inhibitors of endothelin coverting enzyme-1 (ECE-1)

…, K Ahn, AM Sisneros, SB Herman, A Doherty

文献索引：Massa, Mark A.; Patt, William C.; Ahn, Kyunghye; Sisneros, Andre M.; Herman, Sarah B.; Doherty, Annette Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 16 p. 2117 - 2122

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被引用次数: 19

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo-boranes, -tinate or -zincate derivatives.