Journal of medicinal chemistry

Structure-activity studies on sulfamyl diuretics

PW Feit, OBT Nielsen, H Bruun

文献索引：Feit,P.W. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 437 - 440

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被引用次数: 23

摘要

An examination of the structure-activity relationship of thiazide and hydrothiazide diuretics led to the conclusion that apart from other factors a substituent in neighboring position to the sulfonamide group must be present and that compounds having C1, Br, NOz, and CF3 groups in this position are highly active.'In generalizations about structural features that lead to diuretic activity in both the aromatic disulfonamides and the thiazides and their related ...