α 1-Adrenoceptor agonists: the identification of novel α 1A subtype selective 2′-heteroaryl-2-(phenoxymethyl) imidazolines

MJ Bishop, KA Barvian, J Berman, EC Bigham…

文献索引：Bishop, Michael J.; Barvian, Kevin A.; Berman, Judd; Bigham, Eric C.; Garrison, Deanna T.; Gobel, Michael J.; Hodson, Stephen J.; Irving, Paul E.; Liacos, James A.; Navas, Iii, Frank; Saussy Jr., David L.; Speake, Jason D. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 471 - 475

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被引用次数: 21

摘要

Novel 2′-heteroaryl-2-(phenoxymethyl) imidazolines have been identified as potent agonists of the cloned human α1-adrenoceptors in vitro. The nature of the 2′-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. α1A Subtype selective agonists have been identified.